We are happy to announce the publication of our new manuscript: Optimising Transformation Efficiency in Borrelia: Unravelling the Role of the Restriction-Modification System of Borrelia afzelii and Borrelia garinii

The paper discusses our research on how Borrelia species defend themselves against viruses (bacteriophages). Borreliae and other microorganisms identify their own DNA by marking it with a methylation pattern. When a bacteriophage attempts to infect the Borrelia by injecting its DNA, the Borrelia defence mechanism is triggered because the viral DNA lacks the pattern.

Understanding this mechanism has allowed us to modify early passage infectious Borrelia strains, which will aid in further studies on the interactions between ticks, borrelia, and vertebrate hosts.

Additionally, our study may lead to alternative treatment methods for curing Borreliosis. Currently, antibiotics are highly effective, but with the increase in antibiotic-resistant microorganisms, it is crucial to explore other treatment options to ensure the long-term effectiveness of antibiotics.